Unified AMP PD Cohorts

The foundation of AMP PD is predicated on Parkinson’s disease (PD) related study data that is collected,AMPPDVennD harmonized, and made accessible for identifying new biomarkers and developing new treatments for PD. Overcoming challenges associated with resources, time and cost, and data availability is made possible through the collective efforts of the NINDS Parkinson’s Disease Biomarkers Program (PDBP), the Michael J. Fox Foundation (MJFF)’s Parkinson’s Progression Markers Initiative (PPMI), the MJFF BioFIND cohort, and the Harvard Biomarkers Study (HBS). 

When unified, data from these four cohorts offer the PD research community unprecedented access to a large, harmonized dataset with common clinical and genomic data, bridging the gap between prohibitive individual research constraints with large-scale, state-of-the art analysis.

     

    Introduction to the Cohorts

    BioFIND Photo Card

    An observational, cross-sectional, and multi-center study of biomarkers in moderate to advanced PD and control subjects.

    HBS Photo Card

    A powerful incubator for biomarker discovery and precision neurology that can speed up the biomarker test cycle from years to weeks.

    PDBP Photo Card

    Developed to accelerate the discovery of promising new diagnostic and progression biomarkers for Parkinson's disease.

    PPMI Photo Card

    Longitudinal study, contributing comprehensive clinical and imaging data and biological samples to the research community.

    Cohort key criteria selection graphic

     

    Cohort Data & Genetic Criteria

    All AMP PD Cohorts provided clinical data and at least one set of DNA, RNA, and Proteomic assay data. The following criteria was used to assess each of the four Cohorts and provides additional details for why each was selected and found suitable for inclusion:

    • Relevance to PD research
    • Dataset size (cases and controls)
    • Patient consent includes approval for broad data-sharing of de-identified clinical and molecular data
    • Adherence to the AMP PD DUC
    • Longitudinal study method
    • Uniform and standardized clinical data collection instruments
    • Biosample availability with quality control metrics
    • Inclusive of pathological sample data
    • Cost-benefit analysis regarding storage, data harmonization, and analytical costs is in the interest of the AMP PD community

    Unified cohort matrix & key contributions