With the latest update to AMP PD, participant mutation data has been updated to include the APOE genotype for 10,432 participants and additional metadata and QC information is now available for targeted proteomics data. AMP PD is also excited to announce the release of the new Gene Explorer tool from David Craig Laboratories at USC!
Released alongside the AMP PD dataset, GP2 contains 8,644 genotyped participants (5,249 PD, 3,395 non-PD), from both complex and monogenic GP2 networks. New to this release are data from Queen Square Brain Bank, United Kingdom and from the SYNAPS Study, Kazakhstan, as well as monogenic disease data from the PDGENEration cohort.
The AMP PD Terra Workspaces webinar series has grown tremendously this year, covering topics such as “Proteomics Fundamentals in R and Python” and “APOE status across AMP PD subjects and cohorts” in addition to presentations of community workspaces by community contributors.
AMP PD is excited to announce the deployment of the Gene Explorer App, a visualization tool for individual and summary level data developed by the Dr. David Craig Laboratory at USC, within the Terra-based AMP PD Knowledge Platform. This tool provides gene-level integration of RNA-seq with both genomic and clinical data, as well as an examination of quality metrics and interactive tools for exploring clinical and molecular transcriptomics data.
Mary Makarious is a graduate student interested in making sense of the multi-omic characteristics of neurodegenerative diseases such as Parkinson’s Disease. Mary was introduced to the AMP PD team about 3 years ago through her work in Dr. Andy Singleton’s NIA Neurogenetics lab, and has since been integral team member by writing helpful notebooks, trouble-shooting analyses, and helping users feel comfortable with the AMP PD platform. If AMP PD has a user-friendly face, it looks just like Mary, and we are thrilled to introduce you to her here.
Dr. Hirotaka lwaki is a neurologist and researcher with NIH CARD, NIA Laboratory of Neurogenetics, and Data Tecnica International and is serving as co-chair of AMP PD's Data Analysis Working group. Hirotaka combines a deep understanding of the genetics of neurodegenerative disorders with an amazing hands-on facility with data analysis. Hirotaka's expert advice and his meticulous analyses ensured that only the highest quality sequencing data was included in the AMP PD database. We consider it a privilege to count him as a member of the AMP PD team and to introduce him here.